Publications

Betzenhauser MJ, Pitt GS, Antzelevitch C.  2015.  Calcium Channel Mutations in Cardiac Arrhythmia Syndromes.. Curr Mol Pharmacol. 8(2):133-42.

Pitt GS, Lee S-Y.  2016.  Current view on regulation of voltage-gated sodium channels by calcium and auxiliary proteins.. Protein Sci. 25(9):1573-84.

Yang J, Wang Z, Sinden DS, Wang X, Shan B, Yu X, Zhang H, Pitt GS, Wang C.  2016.  FGF13 modulates the gating properties of the cardiac sodium channel Nav1.5 in an isoform-specific manner.. Channels (Austin). 10(5):410-420.

Matsui M, Pitt GS.  2016.  Genetic variants and disease: correlate or cause? Eur Heart J. 37(18):1476-8.

Sun AY, Pitt GS.  2016.  Long QT Syndrome and Seizures.. JACC Clin Electrophysiol. 2(3):277-278.

Wang H-G, Zhu W, Kanter RJ, Silva JR, Honeywell C, Gow RM, Pitt GS.  2016.  A novel NaV1.5 voltage sensor mutation associated with severe atrial and ventricular arrhythmias.. J Mol Cell Cardiol. 92:52-62.

Pablo JLorenzo, Wang C, Presby MM, Pitt GS.  2016.  Polarized localization of voltage-gated Na+ channels is regulated by concerted FGF13 and FGF14 action.. Proc Natl Acad Sci U S A. 113(19):E2665-74.

Black JB, Adler AF, Wang H-G, D'Ippolito AM, Hutchinson HA, Reddy TE, Pitt GS, Leong KW, Gersbach CA.  2016.  Targeted Epigenetic Remodeling of Endogenous Loci by CRISPR/Cas9-Based Transcriptional Activators Directly Converts Fibroblasts to Neuronal Cells.. Cell Stem Cell. 19(3):406-14.

Pitt GS.  2016.  A view from the side-line.. Eur Heart J. 37(47):3488-3489.

Choi J-I, Wang C, Thomas MJ, Pitt GS.  2016.  α1-Syntrophin Variant Identified in Drug-Induced Long QT Syndrome Increases Late Sodium Current.. PLoS One. 11(3):e0152355.

Yan H, Wang C, Marx SO, Pitt GS.  2017.  Calmodulin limits pathogenic Na+ channel persistent current.. J Gen Physiol. 149(2):277-293.

Wang X, Tang H, Wei EQ, Wang Z, Yang J, Yang R, Wang S, Zhang Y, Pitt GS, Zhang H et al..  2017.  Conditional knockout of Fgf13 in murine hearts increases arrhythmia susceptibility and reveals novel ion channel modulatory roles.. J Mol Cell Cardiol. 104:63-74.

Pablo JLorenzo, Pitt GS.  2017.  Divide, multitask, and conquer: Coordination in channel regulation.. Channels (Austin). :1-3.

Pablo JLorenzo, Pitt GS.  2017.  FGF14 is a regulator of KCNQ2/3 channels.. Proc Natl Acad Sci U S A. 114(1):154-159.

Cao C, Ren Y, Barnett AS, Mirando AJ, Rouse D, Mun SHwan, Park-Min K-H, McNulty AL, Guilak F, Karner CM et al..  2017.  Increased Ca2+ signaling through CaV1.2 promotes bone formation and prevents estrogen deficiency-induced bone loss.. JCI Insight. 2(22)

Wei EQ, Sinden DS, Mao L, Zhang H, Wang C, Pitt GS.  2017.  Inducible Fgf13 ablation enhances caveolae-mediated cardioprotection during cardiac pressure overload.. Proc Natl Acad Sci U S A. 114(20):E4010-E4019.

Abraham DM, Lee TE, Watson LJ, Mao L, Chandok G, Wang H-G, Frangakis S, Pitt GS, Shah SH, Wolf MJ et al..  2018.  The two-pore domain potassium channel TREK-1 mediates cardiac fibrosis and diastolic dysfunction.. J Clin Invest. 128(11):4843-4855.

Pitt GS.  2018.  An update on the journey towards precision medicine in cardiology.. Eur Heart J. 39(40):3627-3628.

Cao C, Oswald AB, Fabella BA, Ren Y, Rodriguiz R, Trainor G, Greenblatt MB, Hilton MJ, Pitt GS.  2019.  The Ca1.2 L-type calcium channel regulates bone homeostasis in the middle and inner ear.. Bone. 125:160-168.

Pitt GS, Lee S-Y.  2019.  Ca/CaM interaction with voltage-gated Na channels.. Proc Natl Acad Sci U S A.

Yang L, Katchman A, Kushner J, Kushnir A, Zakharov SI, Chen B-X, Shuja Z, Subramanyam P, Liu G, Papa A et al..  2019.  Cardiac CaV1.2 channels require β subunits for β-adrenergic-mediated modulation but not trafficking.. J Clin Invest. 129(2):647-658.

Sinden DS, Holman CD, Bare CJ, Sun X, Gade AR, Cohen DE, Pitt GS.  2019.  Knockout of the X-linked in the hypothalamic paraventricular nucleus impairs sympathetic output to brown fat and causes obesity.. FASEB J. 33(10):11579-11594.

Wang Z, Vermij SH, Sottas V, Shestak A, Ross-Kaschitza D, Zaklyazminskaya EV, Hudmon A, Pitt GS, Rougier J-S, Abriel H.  2020.  Calmodulin binds to the N-terminal domain of the cardiac sodium channel Nav1.5.. Channels (Austin). 14(1):268-286.

Balestrini S, Mikati MA, Álvarez-García-Rovés R, Carboni M, Hunanyan AS, Kherallah B, McLean M, Prange L, De Grandis E, Gagliardi A et al..  2020.  Cardiac phenotype in ATP1A3-related syndromes: A multicenter cohort study.. Neurology. 95(21):e2866-e2879.

Abrams J, Roybal D, Chakouri N, Katchman AN, Weinberg R, Yang L, Chen B-X, Zakharov SI, Hennessey JA, Avula UMahesh R et al..  2020.  Fibroblast growth factor homologous factors tune arrhythmogenic late NaV1.5 current in calmodulin binding-deficient channels.. JCI Insight. 5(19)