Publications

Matsui M, Bouchareb R, Storto M, Hussain Y, Gregg A, Marx SO, Pitt GS.  2022.  Increased Ca2+ influx through CaV1.2 drives aortic valve calcification.. JCI Insight. 7(5)

Li H, Korcari A, Ciufo D, Mendias CL, Rodeo SA, Buckley MR, Loiselle AE, Pitt GS, Cao C.  2023.  Increased Ca2+ signaling through CaV 1.2 induces tendon hypertrophy with increased collagen fibrillogenesis and biomechanical properties.. FASEB J. 37(7):e23007.

Cao C, Ren Y, Barnett AS, Mirando AJ, Rouse D, Mun SHwan, Park-Min K-H, McNulty AL, Guilak F, Karner CM et al..  2017.  Increased Ca2+ signaling through CaV1.2 promotes bone formation and prevents estrogen deficiency-induced bone loss.. JCI Insight. 2(22)

Wei EQ, Sinden DS, Mao L, Zhang H, Wang C, Pitt GS.  2017.  Inducible Fgf13 ablation enhances caveolae-mediated cardioprotection during cardiac pressure overload.. Proc Natl Acad Sci U S A. 114(20):E4010-E4019.

Gade AR, Marx SO, Pitt GS.  2020.  An interaction between the III-IV linker and CTD in NaV1.5 confers regulation of inactivation by CaM and FHF.. J Gen Physiol. 152(2)

Lin S, Gade AR, Wang H-G, Niemeyer JE, Galante A, DiStefano I, Towers P, Nunez J, Matsui M, Schwartz TH et al..  2025.  Interneuron FGF13 regulates seizure susceptibility via a sodium channel-independent mechanism.. Elife. 13

Sinden DS, Holman CD, Bare CJ, Sun X, Gade AR, Cohen DE, Pitt GS.  2019.  Knockout of the X-linked in the hypothalamic paraventricular nucleus impairs sympathetic output to brown fat and causes obesity.. FASEB J. 33(10):11579-11594.

Sun AY, Pitt GS.  2016.  Long QT Syndrome and Seizures.. JACC Clin Electrophysiol. 2(3):277-278.

Liu G, Papa A, Katchman AN, Zakharov SI, Roybal D, Hennessey JA, Kushner J, Yang L, Chen B-X, Kushnir A et al..  2020.  Mechanism of adrenergic Ca1.2 stimulation revealed by proximity proteomics.. Nature. 577(7792):695-700.

Papa A, Morfin PJDel Rive, Chen B-X, Yang L, Katchman AN, Zakharov SI, Liu G, Bohnen MS, Zheng V, Katz M et al..  2024.  A membrane-associated phosphoswitch in Rad controls adrenergic regulation of cardiac calcium channels.. J Clin Invest. 134(5)

Matsui M, Lynch LE, DiStefano I, Galante A, Gade AR, Wang H-G, Gómez-Banoy N, Towers P, Sinden DS, Wei EQ et al..  2024.  Multiple beta cell-independent mechanisms drive hypoglycemia in Timothy syndrome.. Nat Commun. 15(1):8980.

Pitt GS, Long Y.  2024.  Mutations of Splicing Regulator RBM20 in Atrial Fibrillation.. JACC Basic Transl Sci. 9(2):181-184.

Timothy KW, Bauer R, Larkin KA, Walsh EP, Abrams DJ, Corcia CGonzalez, Valsamakis A, Pitt GS, Dick IE, Golden A.  2024.  A Natural History Study of Timothy Syndrome.. Orphanet J Rare Dis. 19(1):433.

Gade AR, Malvezzi M, Das LTanmoy, Matsui M, Ma C-IJ, Mazdisnian K, Marx SO, Maxfield FR, Pitt GS.  2025.  The NaV1.5 auxiliary subunit FGF13 modulates channels by regulating membrane cholesterol independent of channel binding.. J Clin Invest. 135(20)

Wang H-G, Zhu W, Kanter RJ, Silva JR, Honeywell C, Gow RM, Pitt GS.  2016.  A novel NaV1.5 voltage sensor mutation associated with severe atrial and ventricular arrhythmias.. J Mol Cell Cardiol. 92:52-62.

Pablo JLorenzo, Wang C, Presby MM, Pitt GS.  2016.  Polarized localization of voltage-gated Na+ channels is regulated by concerted FGF13 and FGF14 action.. Proc Natl Acad Sci U S A. 113(19):E2665-74.

Papa A, Zakharov SI, Katchman AN, Kushner JS, Chen B-X, Yang L, Liu G, Jimenez ASanchez, Eisert RJ, Bradshaw GA et al..  2022.  Rad regulation of CaV1.2 channels controls cardiac fight-or-flight response.. Nat Cardiovasc Res. 1(11):1022-1038.

Han Y, Zhu J, Yang L, Nilsson-Payant BE, Hurtado R, Lacko LA, Sun X, Gade AR, Higgins CA, Sisso WJ et al..  2022.  SARS-CoV-2 Infection Induces Ferroptosis of Sinoatrial Node Pacemaker Cells.. Circ Res. 130(7):963-977.

Wang H-G, Bavley CC, Li A, Jones RM, Hackett JE, Bayleyen Y, Lee FS, Rajadhyaksha AM, Pitt GS.  2021.  Scn2a severe hypomorphic mutation decreases excitatory synaptic input and causes autism-associated behaviors.. JCI Insight.

Joglekar A, Prjibelski A, Mahfouz A, Collier P, Lin S, Schlusche AKatharina, Marrocco J, Williams SR, Haase B, Hayes A et al..  2021.  A spatially resolved brain region- and cell type-specific isoform atlas of the postnatal mouse brain.. Nat Commun. 12(1):463.

Lin S, Schwartz TH, Pitt GS.  2025.  Sudden unexpected death in epilepsy: respiratory vs. cardiac contributions.. Cardiovasc Res. 120(18):2385-2394.

Black JB, Adler AF, Wang H-G, D'Ippolito AM, Hutchinson HA, Reddy TE, Pitt GS, Leong KW, Gersbach CA.  2016.  Targeted Epigenetic Remodeling of Endogenous Loci by CRISPR/Cas9-Based Transcriptional Activators Directly Converts Fibroblasts to Neuronal Cells.. Cell Stem Cell. 19(3):406-14.

Wang G, Li J, Bojmar L, Chen H, Li Z, Tobias GC, Hu M, Homan EA, Lucotti S, Zhao F et al..  2023.  Tumour extracellular vesicles and particles induce liver metabolic dysfunction.. Nature. 618(7964):374-382.

Abraham DM, Lee TE, Watson LJ, Mao L, Chandok G, Wang H-G, Frangakis S, Pitt GS, Shah SH, Wolf MJ et al..  2018.  The two-pore domain potassium channel TREK-1 mediates cardiac fibrosis and diastolic dysfunction.. J Clin Invest. 128(11):4843-4855.

Pitt GS.  2018.  An update on the journey towards precision medicine in cardiology.. Eur Heart J. 39(40):3627-3628.